WHAT IS CBD?
The manufacturer of our oils
After harvesting the plants, a supercritical CO2 extraction process is used to produce the highest quality of hemp oil available in the market.
Advantages of supercritical CO2 extraction:
Low extraction temperatures ensure that the full spectrum of beneficial molecules is preserved.
Safe, gentle and environmentally friendly.
CO2 extraction is sustainable.
Hemp contains low levels of THC and has been harvested for centuries in Scandinavia for its plethora of uses. It can be used for many things from rope production to building materials. As such, Scandinavian hemp contains the highest concentrations of CBD available.
- Cannabis medications work so efficiently because of the endocannabinoid (EC) system, present in all humans and many animals as well. This system consists of a series of receptors that are configured only to accept cannabinoids, especially tetrahydrocannabinol (THC) and cannabidiol (CBD). Not enough research has been done on the other ones, cannabinol (CBN) and cannabigerol (CBG) plus others, to know much about their mechanisms of effect.
- This system, an integral part of our physiologies, was discovered in the mid-1990s by Israeli researcher Dr. Ralph Mechoulam who also identified THC as the main active ingredient in cannabis in the early 1960s. Israel has been one of the most progressive nations for cannabis research and currently has one of the most advanced medical marijuana programs in the world.
- Dr. Mechoulam’s world-changing research discovered two main receptors, cannabinoid 1 (CB1) and cannabinoid 2 (CB2), that are keyed to both the endocannabinoids that our body naturally produces and phytocannabinoids (plant-based) like THC and CBD. Our bodies actually produce the ECs similar to how our body produces narcotic-like endorphins. Synthetic cannabinoids, like the ones found in Marinol, also fit the receptor sites but don’t work as efficiently as the natural ones.
- This research barely created a stir when first published as the whole world was still wrapped up in drug war madness. A prominent scientist discovers that our bodies not only have receptor sites cued just for cannabinoids but that our bodies actually produce them internally. The next step was to figure out how this affects our body’s functioning.
- CB1 receptors are primarily found in the brain, although they are also both present in the male and female reproductive organs
- doses and still have it be effective. Additionally, CB1 receptors are not present in the part of the brain that regulates heart rate and respiration, so unlike narcotics, there is no lethal dosage threshold for THC, allowing someone to consume as much is needed for its palliative effects.
- CB2 receptors are primarily found in the immune system with the highest concentration located in the spleen. There is some evidence that the receptors might also be in the micro parts of the brain’s basal ganglia or nerve bundles.
- The CB2 receptors are keyed to CBD and work as an anti-inflammatory agent. The immune-boosting functions of CB2 are far less understood as research into CBD is just really beginning. It’s only been about five years since CBD re-emerged in the medical cannabis scene and was identified through Steephill Labs. The benefits of CBD-rich medicine, with its anti-spasmodic qualities, is one the most exciting and promising areas of cannabis medical research currently happening. One of the other effects of CBD is that it moderates the effects of THC. It actually knocks THC off the CB1 receptor, so if someone is experiencing THC intoxication, a strong dose of CBD can counteract those effects. The future of CBD-rich medicines is almost limitless. Indeed, we have just barely scratched the surface of planet cannabis.
- THC and CBD are the two main cannabinoids that are focused on, however, there are dozens and possibly hundreds more. Some of the ones that have been identified and studied include CBG, which binds to both CB1 as well as CB2 and is an antagonist to CB1, meaning that it moderates the effects of THC.
- Cannabichromene (CBC) is non-psychoactive and has both anti-inflammatory and analgesic properties. CBN occurs when THC degrades. For this reason, it is rarely seen in fresh cannabis and is only mildly psychoactive, having a mostly sleepy effect. Tetrahydrocannabivarin (THCV) is another cannabinoid usually found in central Asian and southern African strains that also acts as a THC antagonist. There are more cannabinoids than can be listed here and they all have the potential to be as life-changing as CBD is turning out to be.
- The fact that there is a system in our body that produces cannabinoids, and is specifically designed to accept just them, should be overwhelming proof of cannabis’ efficacy as a medicine. From the pain-killing effects of THC to the anti-spasmodic and anti-inflammatory properties of CBD, we have just scratched the surface of a world of possibilities. People are waking up to the benefits of these medicines as more researchers are exploring the infinite possibilities inherent in this seemingly simple plant. Future generations will look back and wonder why it took so long to figure this out.
1. The Proven Effectiveness of Whole Plant CBD over Synthetic CBD
A 2015 study by Israeli researchers showed that whole plant CBD-rich cannabis “is superior over [synthetic] CBD for the treatment of inflammatory conditions.”A review of past research into the anti-inflammatory effects of CBD (one of the two most active cannabinoids or special compounds in cannabis) revealed that administration of pure CBD in these pre-clinical studies resulted in a bell-shaped dose-response curve, meaning that CBD stopped having any therapeutic effect beyond a certain amount. The researchers wondered whether a whole plant CBD-rich extract would respond any differently. They discovered that unlike the bell-shaped dose-response curve of pure CBD, the anti-inflammatory, anti-pain response of whole plant CBD increased with dose, making the whole plant CBD ideal for clinical use.
2. The Entourage Effect
To explain why whole plant CBD was more effective than pure CBD, the Israeli scientists surmise, “It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD.”By “other components,” they refer to the approximately 420 additional compounds, including other cannabinoids, terpenes, flavonoids, amino acids, proteins, enzymes, fatty acids, sugars, and so forth
3. The Four Mechanisms of Whole Plant Extract Synergy
In a 2009 review of synergy research in plant medicine, investigators found a rationale for the apparent “pharmacological and therapeutic superiority of many [herbal drug combinations in traditional medicine] in comparison to isolated single constituents.” They define four basic mechanisms of whole plant extract synergy that can be applied to cannabis. As MedicalJane.com reports, these are:
- Ability to affect multiple targets within the body
- Ability to improve the absorption of active ingredients
- Ability to overcome bacterial defense mechanisms
- Ability to minimize adverse side effects
- CBD affects different targets within the body. Terpenes such as caryophyllene help the body with absorbing cannabinoids and several studies demonstrate the anti-bacterial properties of cannabinoids and non-cannabinoid constituents.